Went to my blog to show a coworker my Iron Man christmas comic.. only to be met with a 500 server error.I inspected the error_log and found the culprit to be the Twitconnect plugin not being able to redeclare one of its classes.
I didn't change anything, so I'm not sure why it suddenly decided to have an issue.
I deleted the Twitconnect directory from /wp-content/plugins and that fixed it.